Izingcwaningo Zezokwelapha Zophenyo Lomdlavuza Lwe-colorectal

Sizibophezele emsebenzini wethu wokubhalisa abantu abasisiza ukuthuthukisa impilo yabantu abanomdlavuza. Ucwaningo lwethu lwezokwelapha lomdlavuza we-colorectal lucwaninga ngemithi ephenywayo kuphela, noma kuhlanganise neminye imithi yocwaningo, noma ukwelapha kokunakekelwa okuvamile. Senza ucwaningo ukubona ukuthi lungasisiza yini ukuvimbela, ukuthola, noma ukwelapha umdlavuza.

Imidlavuza yamathumbu nangasemuva (futhi eyaziwa ngokuthi umdlavuza we-colorectal) iqala njenge-polyps, okuwukukhulula okungavamile ngaphakathi kwamathumbu nangasemuva. Uma ingasuswa, lama-polyps angaba umdlavuza. Isigaba IV, noma ngaphezulu somdlavuza we-colorectal, kusho ukuthi amaseli omdlavuza wenanzi noma umdidi asabalalela kwezinye izitho zomzimba.

I-microsatellite instability (MSI) emdlavuzeni wamathumbu nangasemuva

Ukuze ahlelele kahle ukwelashwa kwakho, udokotela wakho kungenzeka afune ukwazi uma kuwukuthi amaseli akho omdlavuza asesemweni se-microsatellite instability-high (MSI-H). Kubantu abaningi, amaphrotheni abizwa ngokuthi i-MMR (i-mismatch repair) alungisa amaphutha aku-DNA. Nokho, kwabanye abantu abanemidlavuza ye-colorectal, izakho zofuzo ezakha amaphrotheni we-MMR azisebenzi kahle futhi lokhu kungenza izingxenye ze-DNA zingasebenzi kahle, okwaziwa ngokuthi uhlelo lwe-MMR (dMMR) olubuthaka. Izimila ezinohlelo lwe-dMMR zingabangela i-microsatellite instability (MSI).